Wednesday, October 28, 2009

Lysocalmspray




Lysocalmspray may be available in the countries listed below.


Ingredient matches for Lysocalmspray



Cetrimide

Cetrimide is reported as an ingredient of Lysocalmspray in the following countries:


  • France

Lidocaine

Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Lysocalmspray in the following countries:


  • France

International Drug Name Search

Sunday, October 25, 2009

Bimectin





Dosage Form: FOR ANIMAL USE ONLY
Bimeda, Inc. Division of Cross Vetpharm Group (ivermectin) Bimectin Pour-On for Cattle ANADA 200-318, Approved by FDA Contains 5 mg ivermectin/mL Parasiticide Consult you veterinarian for assistance in the diagnosis, treatment and control of parasitism. Introduction: Bimectin (ivermectin) Pour-On delivers internal and external control in one convenient low-volume application. Bimectin Pour-On contains ivermectin, a unique chemical entity. ANADA 200-318, Approved by FDA

Indications


Bimectin (ivermectin) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites.


Gastrointestinal Roundworms


Ostertagia ostertagi             (adults and L4)


       (indcluding inhibited state)


Haemonchus placei             (adults and L4)


Trichostrongylus axei          (adults and L4)


Cooperia oncophora            (adults and L4)


Cooperia punctata              (adults and L4)


Cooperia surnabada            (adults and L4)


Strongyloides papillosus      (adults)


Oesophagostomum radiatum     (adults and L4)


Lungworms


Dictyocaulus viviparus           (adults and L4)


Cattle Grubs


Hypoderma bovis


Mites


Sarcoptes scabei var. bovis


Lice


Lingonathus vituli


Haematopinus eurysternus


Damalia bovis


Solenopotes capillatus



Horn Flies


Haematobia irritans


Treatment of Cattle for Horn Flies:  Bimectin (ivermectin) Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing.  For best results Bimectin (ivermectin) Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites.  Consult your veterinarian or an entomologist for the must effective timing of applications.


Persistent Activity:  Bimectin (ivermectin) Pour-On has been proved to effectively control infections and to protect cattle from re-infection with Ostertagia Ostertagi, Oesophagostomum radiatum, Haemonchus placei, Trichostrongyles axei,  Cooperia punctata and Cooperia oncophora for 14 days after treatment.




Dosage


Dosage:  The dose rate is 1 mL for each 22lb of body weight.  The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.


Administration:  Squeeze-Measure-Pour System (1 Liter Bottle with 25 mL Measuring Cap)


Attach metering cap to the bottle.


Select the correct dose rate by rotating the adjuster cap in either direction to position the dose indicator to the appropriate dose.


Gently squeeze the bottle to fill to level (any excess will return to the bottle) and then tip and apply to animal along the topline.


BackPack (84.5 fl oz/2.5 Liter Pack and 169 fl. oz/5 Liter Pack.


Connect the applicator gun to the backpack as follows:  Attach the open end of the draw-off tubing to the dosing equipment.  (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended.  Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage).


Replace the shipping cap with the draw-off cap and tighten down.


Attach draw-off tubing to the draw-off cap.


Gently prime the applicator gun, checking for leaks.


Follow the manufacturer's directions for adjusting the dose.


When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container.  To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.



Free standing 338 fl. oz./10 Liter bottle and 676 fl. oz./20 Liter bottle


Connect the applicator gun to the 338 fl. oz./10 L and 676 fl. oz./20 L bottle as follows: Attach the open end of the draw-off tubing to the dosing equipment.  (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supply Limited, or equivalent is recommended.  Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage.)


Replace the shipping cap with the draw-off cap.


Gently prime the applicator gun, checking for leaks.


Follow the manufacturer's directions for adjusting the dose.


When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container.  To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.



Mode of Action


Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.  This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.  Compounds of this class may also interact with other ligand-gated chloride channel, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).  The margin of safety of compounds of this class is attributable to the fact that mammals do not have the glutamate-gated chloride channel, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channel and they do not readily cross the blood-brain barrier.



Animal Safety


Studies conducted in the U.S.A. have demonstrated the safety margin of ivermectin.  Based on the plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.



Residue Information


Cattle must not be treated within 48 days of slaughter for human consumption.  Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age.  A withdrawal period has not been established for this product in pre-ruminating calves.   Do not use in calves to be processed for veal.



Warning


WARNING!  NOT FOR USE IN HUMANS.


The product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin.  To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves.  If accidental skin contact occurs, wash immediately with soap and water.  If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.


Keep this and all drugs out of the reach of children.


The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information.  To report advers effects, obtain an MSDS or for assistance contact Bimeda, Inc. at 1-888-524-6332.


WARNING!  FLAMMABLE!


KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.



Precautions




Store away from excessive heat (104 degress F/40 degrees C) and protect from light.


Use only in well-ventilated areas or outdoors.


Close container tightly when not in use.


Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced.


Do not use when rain is expected to wet cattle within six hours after treatment.


This product is for application to skin surface only.  Do not give orally or parenterally.


Cloudiness in the formulation may occur when Bimectin (ivermectin) Pour-On is stored at temperatures below 32 degrees F.  Allowing to warm at room temperature will restore the normal appearance without affecting efficacy.


Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g., caked mud or manure.


Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, Bimectin (ivermectin) Pour-On is not recommended for use in species other than cattle.


When to Treat Cattle with Grubs:  Bimectin (ivermectin) Pour-On effectively controls all stages of cattle grubs.  However, proper timing of treatment is important.  For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season.  While this is not peculiar to ivermectin, desctruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas my cause undesirable host-parasite reactions.  Killing Hypoderma lineatum when it is in the esophageal tissues may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis.  Cattle should be treated either before or after these stages of grub development.


Cattle treated with Bimectin (ivermectin) Pour-On at the end of the fly season may be re-treated with ivermectin during the winter without danger of grub-related reactions.  For further information and advice on a planned parasite control program, consult your veterinarian.

Environmental Safety


Studies indicate that when ivermectin comes in contact with soil, it readily and tightly binds too the soil and becomes inactive over time.  Free ivermectin may adversely affect fish or certain aquatic  organisms.  Do not permit cattle to enter lakes, streams, or ponds for at least 6 hours after treatment.  Do not contaminate water by direct application or by the improper disposal of drug containers.  Dispose of containers in an approved landfill or by incineration.


As with other avermectins, ivermectin is excreted in the dung or treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction.  The magnitude and duration of such effects are species and life-cycle specific.  When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependant insects.





Package Information


Bimectin (ivermectin) Pour-On is available in a 33.8 fl oz/1 liter bottle with a measure-pour system, an 84.5 fl. oz/2.5 Liter, a 169 fl. oz/5 Liter, a 338 fl. oz/10 Liter bottle and a 676 fl. oz./20 Liter bottle intended for use with appropriate automatic dosing equipment.



Package Label Display Panel


Bimectin


(ivermectin)


Pour-On for Cattle


Contains 5 mg ivermectin/mL


Parasiticide


Kills:  Roundworms (including Brown Stomach Worm), Lungworms, Grubs, Sucking Lice, Biting Lice, Mange Mites, Horn Flies


Net Contents:  169 fl oz (5 Liter)


WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME AND OTHER SOURCES OF IGNITION.


WARNING! NOT FOR USE IN HUMANS.


ANADA 200-318, Approved by FDA


Bimeda










Bimectin POUR-ON 
ivermectin  solution










Product Information
Product TypeOTC ANIMAL DRUGNDC Product Code (Source)61133-6014
Route of AdministrationTOPICALDEA Schedule    








Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Ivermectin (Ivermectin)Ivermectin5 mg  in 20 L





Inactive Ingredients
Ingredient NameStrength
No Inactive Ingredients Found


















Product Characteristics
Color    Score    
ShapeSize
FlavorImprint Code
Contains      


















Packaging
#NDCPackage DescriptionMultilevel Packaging
161133-6014-220 L In 1 CONTAINERNone
261133-6014-35 L In 1 CARTONNone
361133-6014-15 L In 1 CONTAINERNone










Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
ANADAANADA20031810/01/2009


Labeler - Bimeda, Inc. Division of Cross Vetpharm Group (043653216)
Revised: 12/2009Bimeda, Inc. Division of Cross Vetpharm Group



Saturday, October 24, 2009

Benicar



Generic Name: olmesartan (Oral route)


ol-me-SAR-tan me-DOX-oh-mil


Oral route(Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .



Commonly used brand name(s)

In the U.S.


  • Benicar

Available Dosage Forms:


  • Tablet

Therapeutic Class: Cardiovascular Agent


Pharmacologic Class: Angiotensin II Receptor Antagonist


Uses For Benicar


Olmesartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.


Olmesartan is an angiotensin II receptor blocker. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, olmesartan relaxes blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.


This medicine is available only with your doctor's prescription.


Before Using Benicar


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olmesartan in children.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olmesartan in the elderly.


Pregnancy














Pregnancy CategoryExplanation
1st TrimesterCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd TrimesterDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd TrimesterDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Benazepril

  • Enalapril

  • Enalaprilat

  • Lisinopril

  • Moexipril

  • Perindopril

  • Quinapril

  • Ramipril

  • Trandolapril

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Bromfenac

  • Celecoxib

  • Diclofenac

  • Diflunisal

  • Etodolac

  • Fenoprofen

  • Flurbiprofen

  • Ibuprofen

  • Indomethacin

  • Ketoprofen

  • Ketorolac

  • Magnesium Salicylate

  • Meclofenamate

  • Mefenamic Acid

  • Meloxicam

  • Nabumetone

  • Naproxen

  • Nepafenac

  • Oxaprozin

  • Piroxicam

  • Salsalate

  • Sulindac

  • Tolmetin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Congestive heart failure or

  • Dehydration or

  • Hyponatremia (low sodium in the blood)—Use with caution. May cause side effects to become worse.

  • Kidney disease or

  • Liver disease—Use with caution. The effects may be increased because of slower removal of medicine from the body.

Proper Use of Benicar


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.


In addition to taking this medicine, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.


Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.


Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.


This medicine may be taken with or without food.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets):
    • For high blood pressure:
      • Adults—At first, 20 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 40 mg once a day.

      • Children 6 to 16 years of age weighing 35 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 40 milligrams once a day. If the child cannot swallow the tablets, an oral suspension is recommended.

      • Children 6 to 16 years of age weighing at least 20 kilograms (kg) and less than 35 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 20 milligrams once a day. If the child cannot swallow the tablets, an oral suspension is recommended.

      • Children younger than 6 years of age—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Benicar


It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.


Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.


Dizziness or lightheadedness may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.


Check with your doctor right away if you or your child become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water, which can lead to low blood pressure.


Dizziness, lightheadedness, or fainting may also occur if you or your child exercise or if the weather is hot. Heavy sweating may cause you to lose too much water or salt, which may cause low blood pressure. Use extra care during exercise or hot weather.


Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.


Benicar Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Less common
  • Body aches or pain

  • blood in the urine

  • chills

  • cough or cough producing mucus

  • difficulty with breathing

  • ear congestion

  • fever

  • headache

  • loss of voice

  • nasal congestion

  • runny nose

  • shortness of breath

  • sneezing

  • sore throat

  • tightness in the chest

  • unusual tiredness or weakness

  • wheezing

Rare
  • Bladder pain

  • bloody or cloudy urine

  • bloating or swelling of the face, arms, hands, lower legs, or feet

  • chest pain

  • difficult, burning, or painful urination

  • fast, pounding, or irregular heartbeat or pulse

  • frequent urge to urinate

  • joint pain, stiffness, or swelling

  • large amount of fat in the blood

  • lower back, side, or stomach pain

  • swelling of the feet or lower legs

Incidence not known
  • Dark-colored urine

  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

  • muscle cramps or spasms

  • muscle pain or stiffness

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Blurred vision

  • chest pain or discomfort

  • confusion

  • dizziness, faintness, or lightheadedness

  • sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Abdominal or stomach pain

  • back pain

  • diarrhea

  • dizziness

  • dry mouth

  • flushed, dry skin

  • fruit-like breath odor

  • general feeling of discomfort or illness

  • increased hunger

  • increased thirst

  • increased urination

  • loss of appetite

  • muscle aches and pains

  • nausea

  • pain or tenderness around the eyes and cheekbones

  • shivering

  • tender, swollen glands in the neck

  • trouble sleeping

  • trouble with swallowing

  • troubled breathing

  • unexplained weight loss

  • vomiting

Rare
  • Acid or sour stomach

  • belching

  • difficulty with moving

  • feeling of constant movement of self or surroundings

  • heartburn

  • indigestion

  • rash

  • rapid weight gain

  • sensation of spinning

  • sleeplessness

  • swelling or puffiness of the face

  • tingling of the hands or feet

  • unusual weight gain or loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Benicar side effects (in more detail)



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More Benicar resources


  • Benicar Side Effects (in more detail)
  • Benicar Dosage
  • Benicar Use in Pregnancy & Breastfeeding
  • Drug Images
  • Benicar Drug Interactions
  • Benicar Support Group
  • 62 Reviews for Benicar - Add your own review/rating


  • Benicar Prescribing Information (FDA)

  • Benicar MedFacts Consumer Leaflet (Wolters Kluwer)

  • Benicar Consumer Overview

  • Olmesartan Medoxomil Monograph (AHFS DI)



Compare Benicar with other medications


  • High Blood Pressure
  • Migraine Prevention

Sunday, October 18, 2009

brinzolamide Ophthalmic


brin-ZOE-la-mide


Commonly used brand name(s)

In the U.S.


  • Azopt

In Canada


  • Azopt 1%

Available Dosage Forms:


  • Suspension

Therapeutic Class: Antiglaucoma


Pharmacologic Class: Carbonic Anhydrase Inhibitor


Uses For brinzolamide


Brinzolamide ophthalmic (eye) drops is used to treat increased pressure in the eye caused by open-angle glaucoma or a condition called ocular hypertension. Both eye conditions are caused by high pressure in your eye and can lead to pain from pressure in your eye and then can eventually harm your vision. brinzolamide can help you keep your sight by reducing the pressure in your eye and stopping eye pain.


brinzolamide is available only with your doctor's prescription.


Before Using brinzolamide


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For brinzolamide, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to brinzolamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of brinzolamide eye drops in the pediatric population. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of brinzolamide eye drops in the elderly.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of brinzolamide. Make sure you tell your doctor if you have any other medical problems, especially:


  • Allergy to sulfa drugs—Use with caution. May increase risk for more serious side effects.

  • Cornea (part of the eye) problems, history of or

  • Eye infection or

  • Eye surgery, recent—Use with caution. May make these conditions worse.

  • Kidney disease, severe—Should not be used in patients with this condition.

Proper Use of brinzolamide


Your eye doctor will tell you how much of brinzolamide to use and how often. Do not use more medicine or use it more often than your doctor tells you to.


If you normally wear soft contact lenses, remove them before you use brinzolamide eye drops. Wait at least 15 minutes before putting the contact lenses back in.


To use the eye drops:


  • Wash your hands with soap and water.

  • Shake the eye drops well just before each use.

  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.

  • Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball.

  • Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute.

  • If you think you did not get the drop of medicine into your eye properly, repeat the process with another drop.

  • Do not rinse or wipe the dropper or allow it to touch anything, including your eye.

  • Put the cap on the bottle right away.

  • Wash your hands after using the eye drops to remove any medicine.

  • Never touch the applicator tip to any surface, including the eye, and keep the container tightly closed. This will keep the medicine as germ-free as possible.

If your doctor ordered two different eye drops to be used together, wait at least 10 minutes between the times you apply the medicines. This will help to keep the second medicine from “washing out” the first one.


Dosing


The dose of brinzolamide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of brinzolamide. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For ophthalmic dosage form (eye drops):
    • For glaucoma or hypertension of the eye:
      • Adults—Use one drop in the eye three times a day.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of brinzolamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


You may also keep the medicine in the refrigerator. Also, keep the bottle upright when you are not using it.


Precautions While Using brinzolamide


It is important that your doctor check your progress at regular visits to make sure that brinzolamide is working properly and is not causing unwanted effects.


If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor. These signs may mean that you are allergic to brinzolamide.


Serious allergic reactions may occur while using brinzolamide. Stop using brinzolamide and check with your doctor right away if you have any of the following symptoms: black, tarry stools; blistering, peeling, or loosening of the skin; chills; dark urine; joint or muscle pain; rash; red skin lesions, often with a purple center; sores, ulcers, or white spots in the mouth or on the lips; unusual bleeding or bruising; unusual tiredness or weakness; or yellow eyes or skin.


If you hurt your eye, develop an eye infection, or need to have an eye surgery, talk with your doctor right away. Your doctor may want you to use a new bottle of the eye drops to help prevent an eye infection or keep an infection from getting worse.


brinzolamide may cause some people to have blurred vision for a short time. Make sure you know how you react to brinzolamide before you drive, use machines, or do anything else that could be dangerous if you cannot see properly. Also, since blurred vision may be a sign of a side effect that needs medical attention, check with your doctor if it continues.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


brinzolamide Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Blurred vision

Less common
  • Discharge from the eye

  • dry eyes

  • redness, soreness, irritation, or pain of the eye or eyelid

  • skin rash

Rare
  • Chest pain

  • cough

  • crusting in the corner of the eye

  • difficulty with swallowing

  • dizziness

  • double vision

  • excessive muscle tone

  • eye redness, irritation, or pain

  • fast heartbeat

  • hives

  • itching, swelling, or other signs of eye or eyelid irritation

  • kidney pain

  • muscle stiffness

  • muscle tension or tightness

  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

  • seeing double

  • shortness of breath

  • sore throat

  • tightness in the chest

  • unusual tiredness or weakness

  • wheezing

Incidence not known
  • Abdominal or stomach pain

  • blistering, peeling, or loosening of the skin

  • chills

  • clay-colored stools

  • dark urine

  • diarrhea

  • fever with or without chills

  • general feeling of tiredness or weakness

  • headache

  • hoarseness

  • joint or muscle pain

  • loss of appetite

  • lower back or side pain

  • nausea

  • painful or difficult urination

  • red or irritated eyes

  • red skin lesions, often with a purple center

  • sores, ulcers, or white spots on the lips or in the mouth

  • swollen or painful glands

  • unpleasant breath odor

  • unusual bleeding or bruising

  • vomiting of blood

  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Confusion

  • irregular heartbeat

  • muscle cramps or pain

  • numbness, tingling, pain, or weakness in the hands or feet

  • seizures

  • trembling

  • weakness and heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Bitter, sour, or other unusual taste

Less common
  • Burning, stinging, or discomfort when medicine is applied

  • dry eyes

  • feeling of something in the eye

  • runny nose

  • sneezing

  • stuffy nose

Rare
  • Acid or sour stomach

  • belching

  • body aches or pain

  • congestion

  • difficult or labored breathing

  • dry mouth

  • hair loss

  • heartburn

  • hives or welts

  • indigestion

  • stomach discomfort, upset, or pain

  • tender, swollen glands in the neck

  • thinning of the hair

  • voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: brinzolamide Ophthalmic side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


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More brinzolamide Ophthalmic resources


  • Brinzolamide Ophthalmic Side Effects (in more detail)
  • Brinzolamide Ophthalmic Use in Pregnancy & Breastfeeding
  • Brinzolamide Ophthalmic Drug Interactions
  • Brinzolamide Ophthalmic Support Group
  • 0 Reviews for Brinzolamide Ophthalmic - Add your own review/rating


  • brinzolamide ophthalmic Concise Consumer Information (Cerner Multum)

  • Azopt Prescribing Information (FDA)

  • Azopt Monograph (AHFS DI)

  • Azopt Drops MedFacts Consumer Leaflet (Wolters Kluwer)



Compare brinzolamide Ophthalmic with other medications


  • Glaucoma, Open Angle
  • Intraocular Hypertension

Friday, October 16, 2009

Nimesulene




Nimesulene may be available in the countries listed below.


Ingredient matches for Nimesulene



Nimesulide

Nimesulide is reported as an ingredient of Nimesulene in the following countries:


  • Italy

International Drug Name Search

Wednesday, October 14, 2009

Losartan Stada




Losartan Stada may be available in the countries listed below.


Ingredient matches for Losartan Stada



Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan Stada in the following countries:


  • Germany

  • Spain

International Drug Name Search

Tuesday, October 13, 2009

benzyl alcohol and zinc acetate topical


Generic Name: benzyl alcohol and zinc acetate (topical) (BEN zil AL ka hol)

Brand names: Ivy-Dry Cream, Ivy Dry Super


What is benzyl alcohol and zinc acetate topical?

Benzyl alcohol is an antiseptic that helps prevent the growth of bacteria on the skin.


Zinc acetate is an astringent that shrinks tissues and has a drying effect.


The combination of benzyl alcohol and zinc acetate topical (for the skin) is used to treat itching, skin rash, oozing, or other irritation caused by insect bites or by coming into contact with poison ivy, poison oak, or poison sumac.


Benzyl alcohol and zinc acetate may also be used for purposes not listed in this medication guide.


What is the most important information I should know about benzyl alcohol and zinc acetate topical?


If you are pregnant or breast-feeding, ask your doctor before using this medication.

Call your doctor if your symptoms do not improve after 7 days of treatment with this medication.


Do not use this medication on a child younger than 2 years old without the advice of a doctor.

What should I discuss with my health care provider before using benzyl alcohol and zinc acetate topical?


You should not use this medication if you have ever had an allergic reaction to benzyl alcohol and zinc acetate topical. If you are pregnant or breast-feeding, ask your doctor before using this medication. Do not use this medication on a child younger than 2 years old without the advice of a doctor.

How should I use benzyl alcohol and zinc acetate topical?


Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.


Apply benzyl alcohol and zinc acetate topical to the affected skin areas 1 to 3 times per day.


Call your doctor if your symptoms do not improve after 7 days of treatment with this medication.


Store benzyl alcohol and zinc acetate at room temperature away from moisture and heat.

What happens if I miss a dose?


Since benzyl alcohol and zinc acetate topical is used as needed, it is not likely that you will be on a dosing schedule. Using extra lotion to make up a missed dose will not make the medication more effective.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of topically applied benzyl alcohol and zinc acetate is not likely to occur.


What should I avoid while using benzyl alcohol and zinc acetate topical?


Avoid getting this medication in your eyes. If this does occur, rinse with water.

Benzyl alcohol and zinc acetate topical side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using benzyl alcohol and zinc acetate and call your doctor at once if you have any type of severe skin reaction after applying the lotion.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Benzyl alcohol and zinc acetate Dosing Information


Usual Adult Dose for Dermatitis:

Benzyl alcohol-zinc acetate topical 10%-2% cream,
Benzyl alcohol-zinc acetate topical 10%-2% lotion:
Apply to affected area up to 3 times daily.

Usual Pediatric Dose for Dermatitis:

Benzyl alcohol-zinc acetate topical 10%-2% cream:
2 years or older: Apply to affected area up to 3 times daily.

Benzyl alcohol-zinc acetate topical 10%-2% lotion:
6 years or older: Apply to affected area up to 3 times daily.


What other drugs will affect benzyl alcohol and zinc acetate topical?


It is not likely that other drugs you take orally or inject will have an effect on topically applied benzyl alcohol and zinc acetate. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More benzyl alcohol and zinc acetate resources


  • Benzyl alcohol and zinc acetate Dosage
  • Benzyl alcohol and zinc acetate Support Group
  • 0 Reviews for Benzyl alcohol and zinc acetate - Add your own review/rating


Compare benzyl alcohol and zinc acetate with other medications


  • Dermatitis


Where can I get more information?


  • Your pharmacist can provide more information about benzyl alcohol and zinc acetate.


Monday, October 5, 2009

Dirlotapide




In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0481658-94-0

Chemical Formula

C40-H33-F3-N4-O3

Molecular Weight

674

Therapeutic Category

Antiobesity agent

Chemical Names

N-{(1S)-2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4'-(trifluoromethyl)biphenyl-2-carboxamido]-1H-indol-2-carboxamide (WHO)

1H-Indole-2-carboxamide, 1-methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]- (USAN)

1-Methyl-5-[(4'-trifluormethylbiphenyl-2-carbonyl)amino]-1H-indol-2-carbonsäure-[(S)-(benzylmethylcarbamoyl)phenylmethyl]amid (IUPAC)

5-[4'-(Trifluoromethylbiphenyl-2-carbonyl)amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide

Foreign Names

  • Dirlotapidum (Latin)
  • Dirlotapid (German)
  • Dirlotapide (French)
  • Dirlotapida (Spanish)

Generic Names

  • Dirlotapide (OS: USAN)
  • CP-742033 (IS)

Brand Names

  • Slentrol (veterinary use)
    Pfizer Animal Health, Belgium; Pfizer Animal Health, Switzerland; Pfizer GmbH Tiergesundheit, Germany; Pfizer Limited, Austria; Pfizer Santé Animale, France

International Drug Name Search

Glossary

IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Sunday, October 4, 2009

Tamoxifeno Sandoz




Tamoxifeno Sandoz may be available in the countries listed below.


Ingredient matches for Tamoxifeno Sandoz



Tamoxifen

Tamoxifen is reported as an ingredient of Tamoxifeno Sandoz in the following countries:


  • Poland

Tamoxifen citrate (a derivative of Tamoxifen) is reported as an ingredient of Tamoxifeno Sandoz in the following countries:


  • Argentina

International Drug Name Search

Saturday, October 3, 2009

Skid




Skid may be available in the countries listed below.


Ingredient matches for Skid



Minocycline

Minocycline hydrochloride (a derivative of Minocycline) is reported as an ingredient of Skid in the following countries:


  • Germany

International Drug Name Search