Saturday, December 25, 2010

Sernade




Sernade may be available in the countries listed below.


Ingredient matches for Sernade



Sertraline

Sertraline hydrochloride (a derivative of Sertraline) is reported as an ingredient of Sernade in the following countries:


  • Indonesia

International Drug Name Search

Wednesday, December 22, 2010

budesonide



bue-DES-oh-nide


Commonly used brand name(s)

In the U.S.


  • Entocort EC

In Canada


  • Pulmicort

  • Pulmicort Spacer

Available Dosage Forms:


  • Capsule, Delayed Release

  • Capsule, Extended Release

Therapeutic Class: Endocrine-Metabolic Agent


Pharmacologic Class: Adrenal Glucocorticoid


Uses For budesonide


Budesonide is used to treat an inflammatory bowel disease called Crohn's disease. budesonide works inside the intestine (bowel) to reduce inflammation and symptoms of the disease. It also helps keep the symptoms of Crohn's disease from coming back. Budesonide is a steroid (cortisone-like) medicine.


budesonide is available only with your doctor's prescription.


Before Using budesonide


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For budesonide, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to budesonide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of budesonide in the pediatric population. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of budesonide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving budesonide.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking budesonide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using budesonide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Boceprevir

  • Bupropion

  • Telaprevir

Using budesonide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Erythromycin

  • Itraconazole

  • Ketoconazole

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using budesonide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use budesonide, or give you special instructions about the use of food, alcohol, or tobacco.


  • Grapefruit Juice

Other Medical Problems


The presence of other medical problems may affect the use of budesonide. Make sure you tell your doctor if you have any other medical problems, especially:


  • Cataracts (eye disease) or

  • Diabetes, or a family history of or

  • Glaucoma, or a family history of or

  • Hypertension (high blood pressure) or

  • Infection (e.g., bacteria, virus, fungus) or

  • Osteoporosis (thin bones) or

  • Stomach ulcer, active or history of or

  • Tuberculosis, active or history of or

  • Weakened immune system—Use with caution. May make these conditions worse.

  • Liver disease (including cirrhosis), moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of budesonide


Take budesonide exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking budesonide without first checking with your doctor.


budesonide comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.


Swallow the capsule whole. Do not break, crush, chew, or open it.


Keep using budesonide for the full time of treatment, even if you begin to feel better after a few days. Do not miss any doses.


Dosing


The dose of budesonide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of budesonide. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (capsules):
    • For mild to moderate Crohn's disease:
      • Adults—9 milligrams (mg) once a day in the morning for up to 8 weeks. Your doctor may adjust your dose as needed.

      • Children—Use and dose must be determined by your doctor.


    • For prevention of symptoms of Crohn's disease from coming back:
      • Adults—6 milligrams (mg) once a day in the morning for up to 3 months. Your doctor may adjust your dose as needed.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of budesonide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using budesonide


It is very important that your doctor check your progress at regular visits for any problems or unwanted effects that may be caused by budesonide.


If your condition does not improve or if it become worse, check with your doctor.


Using too much of budesonide or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor if you have more than one of these symptoms while you are using budesonide: darkening of the skin; diarrhea; dizziness; fainting; loss of appetite; mental depression; nausea; skin rash; unusual tiredness or weakness; or vomiting.


You may get infections more easily while using budesonide. Avoid people who are sick or have infections. Tell your doctor right away if you have been exposed to someone with chickenpox or measles.


Make sure any doctor or dentist who treats you knows that you are using budesonide. You may need to stop using budesonide several days before having surgery or medical tests.


Grapefruits and grapefruit juice may increase the effects of budesonide by increasing the amount of budesonide in your body. You should not eat grapefruit or drink grapefruit juice while you are taking budesonide.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


budesonide Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Bruising easily

  • chills

  • colds

  • cough or hoarseness

  • fever

  • flu-like symptoms

  • sneezing

  • sore throat

Less common
  • Abdominal or stomach pain

  • bleeding after defecation

  • blurred vision

  • burning while urinating

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

  • chest pain

  • convulsions

  • cough producing mucus

  • decreased urine

  • diarrhea

  • difficult or labored breathing

  • difficult or painful urination

  • dizziness

  • dry mouth

  • eye pain

  • fast, irregular, pounding, or racing heartbeat or pulse

  • feeling of warmth

  • general feeling of discomfort or illness

  • headache

  • heartburn

  • increase in body movements

  • increased thirst

  • increased urge to urinate during the night

  • irregular heartbeat

  • joint pain

  • loss of appetite

  • mood changes

  • muscle aches and pains

  • nausea or vomiting

  • nervousness

  • numbness or tingling in the hands, feet, or lips

  • pain or discomfort in the chest, upper stomach, or throat

  • pounding in the ears

  • rectal bleeding

  • redness of the face, neck, arms, and occasionally, upper chest

  • runny nose

  • severe constipation

  • shakiness in the legs, arms, hands, or feet

  • shivering

  • shortness of breath

  • slow or fast heartbeat

  • stomach cramps

  • sweating

  • swelling of the legs and feet

  • swelling or puffiness of the face

  • tightness in the chest

  • trouble sleeping

  • uncomfortable swelling around the anus

  • unusual tiredness or weakness

  • waking to urinate at night

  • weight gain

  • weight loss

  • wheezing

Incidence not known
  • Bulging soft spot on the head of an infant

  • change in the ability to see colors, especially blue or yellow

  • difficulty with swallowing

  • hives

  • itching

  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

  • skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Acid or sour stomach

  • belching

  • blemishes on the skin

  • heartburn

  • indigestion

  • pain or tenderness around the eyes and cheekbones

  • pimples

  • rounded or moon face

  • stomach discomfort, upset, or pain

  • stuffy nose

Less common
  • Accumulation of pus

  • agitation

  • blistering, crusting, irritation, itching, or reddening of the skin

  • change in hearing

  • changes in vision

  • cracked, dry, or scaly skin

  • cracks in the skin at the corners of mouth

  • difficulty with moving

  • dizziness or lightheadedness

  • ear drainage

  • earache or pain in the ear

  • feeling of constant movement of self or surroundings

  • hair loss or thinning of the hair

  • increased appetite

  • increased hair growth, especially on the face

  • lack or loss of strength

  • loss of memory

  • muscle pains or stiffness

  • nervousness

  • pain, swelling, or redness in the joints

  • pinpoint red or purple spots on the skin

  • problems with memory

  • redness, swelling, or soreness of the tongue

  • sensation of spinning

  • skin rash

  • skin rash, encrusted, scaly, and oozing

  • sleepiness or unusual drowsiness

  • sleeplessness

  • soreness or redness around the fingernails and toenails

  • swollen joints

  • unable to sleep

  • uterine bleeding between menstrual periods

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More budesonide resources


  • Budesonide Use in Pregnancy & Breastfeeding
  • Budesonide Drug Interactions
  • Budesonide Support Group
  • 22 Reviews for Budesonide - Add your own review/rating


  • budesonide Concise Consumer Information (Cerner Multum)

  • Budesonide Professional Patient Advice (Wolters Kluwer)

  • Budesonide Powder MedFacts Consumer Leaflet (Wolters Kluwer)

  • Budesonide Monograph (AHFS DI)

  • Entocort EC Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Entocort EC Prescribing Information (FDA)

  • Pulmicort Flexhaler Prescribing Information (FDA)

  • Pulmicort Flexhaler Concise Consumer Information (Cerner Multum)

  • Pulmicort Respules Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

  • Pulmicort Turbuhaler Powder MedFacts Consumer Leaflet (Wolters Kluwer)



Compare budesonide with other medications


  • Asthma, Maintenance
  • Autoimmune Hepatitis
  • Crohn's Disease
  • Crohn's Disease, Acute
  • Crohn's Disease, Maintenance
  • Eosinophilic Esophagitis
  • Inflammatory Bowel Disease

Monday, December 20, 2010

Liprolog Mix25




Liprolog Mix25 may be available in the countries listed below.


Ingredient matches for Liprolog Mix25



Insulin Lispro

Insulin Lispro biphasic (a derivative of Insulin Lispro) is reported as an ingredient of Liprolog Mix25 in the following countries:


  • Germany

International Drug Name Search

Saturday, December 11, 2010

Levuloza




Levuloza may be available in the countries listed below.


Ingredient matches for Levuloza



Fructose

Fructose is reported as an ingredient of Levuloza in the following countries:


  • Bosnia & Herzegowina

  • Serbia

International Drug Name Search

Thursday, December 9, 2010

Biperiden


Generic Name: Biperiden (bye-PER-i-den)
Brand Name: Akineton


Biperiden is used for:

Treating Parkinson disease and other Parkinson-like disorders. It is used to treat certain side effects (eg, involuntary movements) caused by certain medicines. It may also be used for other conditions as determined by your doctor.


Biperiden is an anticholinergic. It works by helping to correct the chemical imbalance thought to cause Parkinson-type disorders.


Do NOT use Biperiden if:


  • you are allergic to any ingredient in Biperiden

  • you have narrow-angle glaucoma, narrowing of the esophagus, stomach or bowel problems (eg, blockage, ulcerative colitis, megacolon), heart problems caused by bleeding, myasthenia gravis, or difficulty urinating

Contact your doctor or health care provider right away if any of these apply to you.



Before using Biperiden:


Some medical conditions may interact with Biperiden. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have irregular heartbeat, epilepsy or seizures, an enlarged prostate, or a history of involuntary movements of the tongue, lips, face, or extremities caused by medicines

  • if you are at risk for glaucoma

Some MEDICINES MAY INTERACT with Biperiden. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Antihistamines (eg, chlorpheniramine), certain narcotics (eg, meperidine), phenothiazines (eg, chlorpromazine), tricyclic antidepressants (eg, amitriptyline), or certain antiarrhythmics (eg, quinidine) because the risk of side effects, such as dry mouth, difficulty urinating, and constipation, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Biperiden may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Biperiden:


Use Biperiden as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Biperiden may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

  • If you miss a dose of Biperiden, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Biperiden.



Important safety information:


  • Biperiden may cause blurred vision, dizziness, lightheadedness, or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Biperiden. Using Biperiden alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Biperiden may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.

  • Do not drink alcohol while you are taking Biperiden.

  • Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.

  • Sucking on sugarless hard candy, drinking fluids, or practicing good dental hygiene can relieve dry mouth.

  • Use Biperiden with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Biperiden during pregnancy. It is unknown if Biperiden is excreted in breast milk. If you are or will be breast-feeding while you are taking Biperiden, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Biperiden:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Biperiden side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dilated pupils; disorientation; fast breathing; fast heart rate; fever; hallucination; hot or flushed skin; hyperactivity; loss of consciousness; loss of memory; muscle incoordination; paralysis; seizures.


Proper storage of Biperiden:

Store Biperiden at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Biperiden out of the reach of children and away from pets.


General information:


  • If you have any questions about Biperiden, please talk with your doctor, pharmacist, or other health care provider.

  • Biperiden is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Biperiden. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Biperiden resources


  • Biperiden Side Effects (in more detail)
  • Biperiden Use in Pregnancy & Breastfeeding
  • Biperiden Drug Interactions
  • Biperiden Support Group
  • 0 Reviews for Biperiden - Add your own review/rating


  • Biperiden Professional Patient Advice (Wolters Kluwer)

  • biperiden Concise Consumer Information (Cerner Multum)

  • biperiden Advanced Consumer (Micromedex) - Includes Dosage Information

  • Biperiden Hydrochloride Monograph (AHFS DI)



Compare Biperiden with other medications


  • Extrapyramidal Reaction
  • Parkinson's Disease

Thursday, December 2, 2010

Bupropion



Pronunciation: bue-PROE-pee-on
Generic Name: Bupropion
Brand Name: Wellbutrin

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Bupropion outweigh the risks.


Bupropion contains the same ingredient that is in Zyban, a medicine used to help certain patients stop smoking. Some patients using bupropion to help them stop smoking have also developed depression and certain other mental or mood problems, including suicidal thoughts or actions.


Family and caregivers must closely watch patients who take Bupropion. It is important to keep in close contact with the patient's doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation, hostility, depressed mood, or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the patient's doctor.





Bupropion is used for:

Treating depression. It may also be used for other conditions as determined by your doctor.


Bupropion is an antidepressant. It works in the brain to treat depression. Exactly how it works is not known.


Do NOT use Bupropion if:


  • you are allergic to any ingredient in Bupropion

  • you are taking any other medicine that contains bupropion

  • you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)

  • you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use

  • you are taking or have taken linezolid, methylene blue, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Video: Treatment for Depression







Treatments for depression are getting better everyday and there are things you can start doing right away.






Before using Bupropion:


Some medical conditions may interact with Bupropion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse

  • if you have diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), or a recent heart attack

  • if you have a history of seizures, a head injury, or a tumor in the brain or spinal cord

  • if you are taking nonprescription weight loss medicines or stimulants

Some MEDICINES MAY INTERACT with Bupropion. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Amantadine, other antidepressants (eg, amitriptyline, fluvoxamine), antipsychotics (eg, haloperidol, risperidone), clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, HIV protease inhibitors (eg, nelfinavir), insulin, levodopa, linezolid, MAOIs (eg, phenelzine), methylene blue, nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, sympathomimetics (eg, pseudoephedrine), theophylline, thiotepa, tiagabine, or ticlopidine because they may increase the risk of Bupropion's side effects

  • Carbamazepine, efavirenz, phenobarbital, phenytoin, rifampin, or ritonavir because they may decrease Bupropion's effectiveness

  • Antiarrhythmics (eg, flecainide, propafenone), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Bupropion

  • Tamoxifen because its effectiveness may be decreased by Bupropion, which may lead to an increased risk of breast cancer recurrence in women with a history of breast cancer

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bupropion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Bupropion:


Use Bupropion as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Bupropion comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Bupropion refilled.

  • Take Bupropion by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

  • Several weeks may pass before your symptoms improve. Do not stop taking Bupropion without checking with your doctor.

  • Take your doses at the same times each day, at least 6 hours apart unless directed otherwise by your doctor. This may help to decrease the risk of seizures with Bupropion.

  • Continue to take Bupropion even if you feel well. Do not miss any doses.

  • If you miss a dose of Bupropion, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 6 hours. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bupropion.



Important safety information:


  • Bupropion may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Bupropion with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Bupropion; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Bupropion may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Bupropion.

  • If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.

  • Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Bupropion without first checking with your doctor. They may increase your risk of seizures.

  • The risk of seizures may be greater if you take Bupropion in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Bupropion for longer than prescribed without checking with your doctor.

  • Children, teenagers, and young adults who take Bupropion may be at increased risk of suicidal thoughts or actions. Watch all patients who take Bupropion closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

  • If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.

  • Bupropion contains the same ingredients as Zyban, a medicine used to help stop smoking, and Aplenzin, another medicine used to treat depression. Do not take Bupropion if you are also taking Zyban or Aplenzin. Discuss any questions or concerns with your doctor.

  • Bupropion may interfere with certain lab tests, including urine screenings for amphetamines. Be sure your doctor and lab personnel know you are taking Bupropion.

  • Use Bupropion with caution in the ELDERLY; they may be more sensitive to its effects.

  • Bupropion should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bupropion while you are pregnant. Bupropion is found in breast milk. Do not breast-feed while taking Bupropion.


Possible side effects of Bupropion:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Changes in appetite; constipation; dizziness; drowsiness; dry mouth; headache; increased sweating; nausea; nervousness; restlessness; taste changes; trouble sleeping; vomiting; weight changes.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue, unusual hoarseness); blurred vision or other vision changes; changes in sexual desire or ability; chest pain; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; hearing problems; menstrual changes; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); pale stools; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent joint or muscle pain; severe or persistent nausea, vomiting, or stomach pain; severe or persistent nervousness, restlessness, or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor; unusual swelling; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Bupropion side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; loss of consciousness; rigid or painful muscles; seizures; severe dizziness; slow or difficult breathing.


Proper storage of Bupropion:

Store Bupropion at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Bupropion out of the reach of children and away from pets.


General information:


  • If you have any questions about Bupropion, please talk with your doctor, pharmacist, or other health care provider.

  • Bupropion is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bupropion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bupropion resources


  • Bupropion Side Effects (in more detail)
  • Bupropion Dosage
  • Bupropion Use in Pregnancy & Breastfeeding
  • Drug Images
  • Bupropion Drug Interactions
  • Bupropion Support Group
  • 325 Reviews for Bupropion - Add your own review/rating


  • Bupropion Professional Patient Advice (Wolters Kluwer)

  • Bupropion Prescribing Information (FDA)

  • Aplenzin Consumer Overview

  • Aplenzin Prescribing Information (FDA)

  • Budeprion XL Prescribing Information (FDA)

  • Bupropion Hydrochloride Monograph (AHFS DI)

  • Wellbutrin Prescribing Information (FDA)

  • Wellbutrin Consumer Overview

  • Wellbutrin SR Prescribing Information (FDA)

  • Wellbutrin XL Prescribing Information (FDA)

  • Zyban Prescribing Information (FDA)

  • Zyban Consumer Overview

  • bupropion Advanced Consumer (Micromedex) - Includes Dosage Information



Compare Bupropion with other medications


  • ADHD
  • Anxiety
  • Bipolar Disorder
  • Depression
  • Dysthymia
  • Migraine Prevention
  • Obesity
  • Panic Disorder
  • Premenstrual Dysphoric Disorder
  • Seasonal Affective Disorder
  • Sexual Dysfunction, SSRI Induced
  • Smoking Cessation

Cipronatin




Cipronatin may be available in the countries listed below.


Ingredient matches for Cipronatin



Ciprofloxacin

Ciprofloxacin is reported as an ingredient of Cipronatin in the following countries:


  • Turkey

International Drug Name Search

Saturday, November 27, 2010

Anti-Gripe Asclépius




Anti-Gripe Asclépius may be available in the countries listed below.


Ingredient matches for Anti-Gripe Asclépius



Paracetamol

Paracetamol is reported as an ingredient of Anti-Gripe Asclépius in the following countries:


  • Portugal

International Drug Name Search

Friday, November 26, 2010

Benpéridol




Benpéridol may be available in the countries listed below.


Ingredient matches for Benpéridol



Benperidol

Benpéridol (DCF) is also known as Benperidol (Rec.INN)

International Drug Name Search

Glossary

DCFDénomination Commune Française
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Wednesday, November 24, 2010

Saroten




Saroten may be available in the countries listed below.


Ingredient matches for Saroten



Amitriptyline

Amitriptyline is reported as an ingredient of Saroten in the following countries:


  • Taiwan

Amitriptyline hydrochloride (a derivative of Amitriptyline) is reported as an ingredient of Saroten in the following countries:


  • Austria

  • Bahrain

  • Bangladesh

  • Denmark

  • Egypt

  • Estonia

  • Germany

  • Greece

  • Iceland

  • Iran

  • Iraq

  • Jordan

  • Kuwait

  • Latvia

  • Lebanon

  • Oman

  • Qatar

  • Russian Federation

  • Saudi Arabia

  • Sri Lanka

  • Sudan

  • Sweden

  • Switzerland

  • United Arab Emirates

  • Yemen

International Drug Name Search

Sunday, November 21, 2010

Doc Fluconazol




Doc Fluconazol may be available in the countries listed below.


Ingredient matches for Doc Fluconazol



Fluconazole

Fluconazole is reported as an ingredient of Doc Fluconazol in the following countries:


  • Belgium

International Drug Name Search

Friday, November 19, 2010

Marovilina




Marovilina may be available in the countries listed below.


Ingredient matches for Marovilina



Ampicillin

Ampicillin trihydrate (a derivative of Ampicillin) is reported as an ingredient of Marovilina in the following countries:


  • Mexico

International Drug Name Search

Zantac 300


See also: Generic Zantac, Generic Zantac 150


Zantac 300 is a brand name of ranitidine, approved by the FDA in the following formulation(s):


ZANTAC 300 (ranitidine hydrochloride - tablet; oral)



  • Manufacturer: GLAXOSMITHKLINE

    Approval date: December 9, 1985

    Strength(s): EQ 300MG BASE [RLD][AB]

Has a generic version of Zantac 300 been approved?


Yes. The following products are equivalent to Zantac 300:


ranitidine hydrochloride tablet; oral



  • Manufacturer: AMNEAL PHARMS NY

    Approval date: October 13, 2006

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: APOTEX

    Approval date: September 12, 1997

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: DR REDDYS LABS INC

    Approval date: July 27, 2005

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: GLENMARK GENERICS

    Approval date: November 19, 2008

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: IVAX SUB TEVA PHARMS

    Approval date: September 30, 1998

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: MYLAN

    Approval date: August 22, 1997

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: PAR PHARM

    Approval date: January 28, 1999

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: SANDOZ

    Approval date: August 29, 1997

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: TEVA

    Approval date: July 31, 1997

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: WATSON LABS

    Approval date: October 20, 1997

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: WATSON LABS

    Approval date: December 19, 2005

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: WOCKHARDT

    Approval date: December 17, 1998

    Strength(s): EQ 300MG BASE [AB]


  • Manufacturer: WOCKHARDT

    Approval date: December 11, 2009

    Strength(s): EQ 300MG BASE [AB]

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Zantac 300. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents

There are no current U.S. patents associated with Zantac 300.

See also...

  • Zantac 300 Consumer Information (Cerner Multum)
  • Ranitidine Consumer Information (Drugs.com)
  • Ranitidine Consumer Information (Wolters Kluwer)
  • Ranitidine Effervescent Tablets Consumer Information (Wolters Kluwer)
  • Ranitidine Syrup Consumer Information (Wolters Kluwer)
  • Ranitidine Tablets Consumer Information (Wolters Kluwer)
  • Ranitidine Consumer Information (Cerner Multum)
  • Ranitidine Hydrochloride AHFS DI Monographs (ASHP)

Wednesday, November 17, 2010

Analginas L




Analginas L may be available in the countries listed below.


Ingredient matches for Analginas L



Metamizole

Metamizole is reported as an ingredient of Analginas L in the following countries:


  • Lithuania

International Drug Name Search

Sunday, November 14, 2010

Diphenidol Hydrochloride




Diphenidol Hydrochloride may be available in the countries listed below.


Ingredient matches for Diphenidol Hydrochloride



Difenidol

Diphenidol Hydrochloride (USAN) is also known as Difenidol (Rec.INN)

International Drug Name Search

Glossary

Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Allernix




Allernix may be available in the countries listed below.


Ingredient matches for Allernix



Diphenhydramine

Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Allernix in the following countries:


  • Canada

International Drug Name Search

Saturday, November 6, 2010

Zoamco




Zoamco may be available in the countries listed below.


Ingredient matches for Zoamco



Atorvastatin

Atorvastatin calcium (a derivative of Atorvastatin) is reported as an ingredient of Zoamco in the following countries:


  • Vietnam

International Drug Name Search

Broncoxol




Broncoxol may be available in the countries listed below.


Ingredient matches for Broncoxol



Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Broncoxol in the following countries:


  • Ecuador

International Drug Name Search

Friday, November 5, 2010

B & O Supprettes Suppositories


Pronunciation: bell-a-DON-a/OH-pee-um
Generic Name: Belladonna Alkaloids/Opium
Brand Name: B & O Supprettes


B & O Supprettes Suppositories are used for:

Treating moderate to severe pain due to spasms of the urinary tract.


B & O Supprettes Suppositories are an anticholinergic and analgesic combination. It works by relaxing the smooth muscle of the urinary tract and relieving pain.


Do NOT use B & O Supprettes Suppositories if:


  • you are allergic to any ingredient in B & O Supprettes Suppositories

  • you are in premature labor

  • you have severe bowel motility problems (eg, paralytic ileus), severe diarrhea associated with antibiotic use (pseudomembranous colitis), glaucoma, severe liver or kidney disease, bronchial asthma or severe breathing problems, or a seizure disorder

  • you have alcohol-withdrawal symptoms or you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.



Before using B & O Supprettes Suppositories:


Some medical conditions may interact with B & O Supprettes Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems

  • if you have a history of recent head injury, increased pressure in the brain, brain blood vessel problems, growths in the brain (eg, tumors), or seizures

  • if you have a history of heart problems, low blood pressure, liver or kidney problems, an underactive thyroid, adrenal gland problems (eg, Addison disease), stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria

  • if you have a history of substance or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with B & O Supprettes Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Cimetidine, furazolidone, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), or sodium oxybate (GHB) because the risk of side effects, such as severe drowsiness, slow or difficult breathing, confusion, and seizures, may be increased

  • Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of B & O Supprettes Suppositories may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if B & O Supprettes Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use B & O Supprettes Suppositories:


Use B & O Supprettes Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Remove the wrapper and moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum, then use your finger to push it in completely. Wash your hands thoroughly after using B & O Supprettes Suppositories.

  • Do not exceed the recommended dose or take B & O Supprettes Suppositories for longer than prescribed without checking with your doctor. Exceeding the recommended dose or taking B & O Supprettes Suppositories for longer than prescribed may be habit-forming.

  • If you miss a dose of B & O Supprettes Suppositories and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use B & O Supprettes Suppositories.



Important safety information:


  • B & O Supprettes Suppositories may cause drowsiness, dizziness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to B & O Supprettes Suppositories. Using B & O Supprettes Suppositories alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking B & O Supprettes Suppositories. B & O Supprettes Suppositories will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

  • B & O Supprettes Suppositories may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.

  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using B & O Supprettes Suppositories.

  • Use B & O Supprettes Suppositories with caution in the ELDERLY because they may be more sensitive to its effects

  • B & O Supprettes Suppositories are not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking B & O Supprettes Suppositories, discuss with your doctor the benefits and risks of using B & O Supprettes Suppositories during pregnancy. It is unknown if B & O Supprettes Suppositories are excreted in breast milk. If you are or will be breast-feeding while you are using B & O Supprettes Suppositories, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, B & O Supprettes Suppositories may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if B & O Supprettes Suppositories stops working well. Do not take more than prescribed.


When used for long periods of time or at high doses, some people develop a need to continue taking B & O Supprettes Suppositories. This is known as DEPENDENCE or addiction.


If you suddenly stop taking B & O Supprettes Suppositories, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.



Possible side effects of B & O Supprettes Suppositories:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Blurred vision; constipation; difficulty urinating; dizziness; drowsiness; dry mouth; fast pulse; nausea; sensitivity to light; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eye pain.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: B & O Supprettes side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include anxiety; clumsiness; coma; decreased sweating; difficulty swallowing; dry mouth; elevated body temperature; fever; foul-smelling breath; heart attack; hot, dry, flushed skin; hyperactivity; irritability; loss of consciousness; loss of coordination; pinpoint or dilated pupils; seizures; shock; slowed or difficult breathing; stupor.


Proper storage of B & O Supprettes Suppositories:

Store B & O Supprettes Suppositories at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not refrigerate. Store away from heat, moisture, and light. Do not store in the bathroom. Keep B & O Supprettes Suppositories out of the reach of children and away from pets.


General information:


  • If you have any questions about B & O Supprettes Suppositories, please talk with your doctor, pharmacist, or other health care provider.

  • B & O Supprettes Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about B & O Supprettes Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More B & O Supprettes resources


  • B & O Supprettes Side Effects (in more detail)
  • B & O Supprettes Use in Pregnancy & Breastfeeding
  • B & O Supprettes Drug Interactions
  • B & O Supprettes Support Group
  • 2 Reviews for B & O Supprettes - Add your own review/rating


Compare B & O Supprettes with other medications


  • Overactive Bladder

Milibis




Milibis may be available in the countries listed below.


Ingredient matches for Milibis



Glycobiarsol

Glycobiarsol is reported as an ingredient of Milibis in the following countries:


  • Bahrain

  • Cyprus

  • Egypt

  • Jordan

  • Kuwait

  • Lebanon

  • Qatar

  • Saudi Arabia

  • United Arab Emirates

International Drug Name Search

Caliprene




Caliprene may be available in the countries listed below.


Ingredient matches for Caliprene



Pilocarpine

Pilocarpine hydrochloride (a derivative of Pilocarpine) is reported as an ingredient of Caliprene in the following countries:


  • Mexico

International Drug Name Search

Tuesday, November 2, 2010

Domerid




Domerid may be available in the countries listed below.


Ingredient matches for Domerid



Domperidone

Domperidone maleate (a derivative of Domperidone) is reported as an ingredient of Domerid in the following countries:


  • Ireland

International Drug Name Search

Monday, November 1, 2010

Sindolan




Sindolan may be available in the countries listed below.


Ingredient matches for Sindolan



Naproxen

Naproxen sodium salt (a derivative of Naproxen) is reported as an ingredient of Sindolan in the following countries:


  • Ecuador

International Drug Name Search

Monday, October 25, 2010

BPM PE


Generic Name: brompheniramine and phenylephrine (BROM fen IR a meen and FEN il EFF rin)

Brand Names: Alacol, Alenaze-D, Alenaze-D NR, B-Vex D, BPM PE, Brom Tann PE, Bromfed, Bromfed-PD Capsules, BroveX ADT, BroveX PEB, Brovex-D, Children's Cold & Allergy, Dimaphen Elixir, Dimetapp Cold & Allergy, Entre-B, J-Tan D, J-Tan D SR, Phenyl 15/12mg, Phenyl 7.5/6mg, RespaHist II, Rhinabid, Rhinabid PD, Seradex-LA, Tanabid SR, V-Hist, VazoBid, VaZol-D, Vazotab, Zotex-PE


What is BPM PE (brompheniramine and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of brompheniramine and phenylephrine is used to treat nasal congestion, sneezing, itching, watery eyes, and runny nose caused by allergies, hay fever, and the common cold.


Brompheniramine and phenylephrine may also be used for purposes not listed in this medication guide.


What is the most important information I should know about BPM PE (brompheniramine and phenylephrine)?


Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist about taking brompheniramine and phenylephrine if you have heart disease or high blood pressure, diabetes, a thyroid disorder, glaucoma, kidney disease, an enlarged prostate, or problems with urination.


What should I discuss with my healthcare provider before taking BPM PE (brompheniramine and phenylephrine)?


You should not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take brompheniramine and phenylephrine if you have:



  • heart disease or high blood pressure;




  • diabetes;




  • a thyroid disorder;




  • glaucoma;




  • kidney disease;




  • an enlarged prostate; or




  • problems with urination.




FDA pregnancy category C. It is not known whether brompheniramine and phenylephrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Brompheniramine and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take BPM PE (brompheniramine and phenylephrine)?


Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.


Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take the medicine with a full glass of water. Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before you swallow it.


Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.


Shake the oral suspension (liquid) well just before you measure a dose. Do not take brompheniramine and phenylephrine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. Store at room temperature away from moisture and heat.

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).


What should I avoid while taking BPM PE (brompheniramine and phenylephrine)?


This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.


Drinking alcohol can increase certain side effects of brompheniramine and phenylephrine. Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.


BPM PE (brompheniramine and phenylephrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeat;




  • severe dizziness, anxiety, restless feeling, or nervousness;




  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;




  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or




  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).



Less serious side effects may include:



  • drowsiness or dizziness;




  • blurred vision;




  • dry mouth, nose, or throat;




  • mild stomach pain, constipation;




  • problems with memory or concentration;




  • feeling restless or excited (especially in children);




  • sleep problems (insomnia); or




  • warmth, redness, or tingly feeling under your skin.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect BPM PE (brompheniramine and phenylephrine)?


Before using brompheniramine and phenylephrine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by brompheniramine and phenylephrine.

Tell your doctor about all other medications you are using, especially:



  • medicines to treat high blood pressure;




  • a beta blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or




  • antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.



This list is not complete and other drugs may interact with brompheniramine and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More BPM PE resources


  • BPM PE Side Effects (in more detail)
  • BPM PE Use in Pregnancy & Breastfeeding
  • BPM PE Drug Interactions
  • BPM PE Support Group
  • 0 Reviews for BPM PE - Add your own review/rating


  • Alenaze-D Elixir MedFacts Consumer Leaflet (Wolters Kluwer)

  • Bromfed MedFacts Consumer Leaflet (Wolters Kluwer)

  • BroveX-D Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

  • Entre-B Prescribing Information (FDA)

  • J-Tan D Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Rhinabid Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)



Compare BPM PE with other medications


  • Hay Fever
  • Nasal Congestion
  • Rhinitis


Where can I get more information?


  • Your pharmacist can provide more information about brompheniramine and phenylephrine.

See also: BPM PE side effects (in more detail)


Sunday, October 24, 2010

Enalapril-corax




Enalapril-corax may be available in the countries listed below.


Ingredient matches for Enalapril-corax



Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril-corax in the following countries:


  • Germany

International Drug Name Search

Monday, October 18, 2010

Benzoyl Peroxide Cloths


Pronunciation: BEN-zoe-il per-OX-ide
Generic Name: Benzoyl Peroxide
Brand Name: Triaz


Benzoyl Peroxide Cloths are used for:

Treating acne.


Benzoyl Peroxide Cloths are a keratolytic agent with antibacterial actions. The effectiveness of benzoyl peroxide appears to be due to its antibacterial, peeling (keratolytic), and drying actions.


Do NOT use Benzoyl Peroxide Cloths if:


  • you are allergic to any ingredient in Benzoyl Peroxide Cloths

Contact your doctor or health care provider right away if any of these apply to you.



Before using Benzoyl Peroxide Cloths:


Some medical conditions may interact with Benzoyl Peroxide Cloths. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Benzoyl Peroxide Cloths. However, no specific interactions with Benzoyl Peroxide Cloths are known at this time.


Ask your health care provider if Benzoyl Peroxide Cloths may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Benzoyl Peroxide Cloths:


Use Benzoyl Peroxide Cloths as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Wet the affected area with water. Wet the cloth with a little water and work into a full lather. Cleanse the affected area with the cloth for 10 to 20 seconds. Rinse the affected area thoroughly with water and pat dry.

  • Throw the cloth away. Do not flush.

  • Wash your hands immediately after using Benzoyl Peroxide Cloths.

  • If you miss a dose of Benzoyl Peroxide Cloths, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Benzoyl Peroxide Cloths.



Important safety information:


  • Use on the skin only. Avoid getting Benzoyl Peroxide Cloths in your eyes, eyelids, on the inside of your nose or mouth, on highly inflamed or damaged skin, or on your lips. If you get Benzoyl Peroxide Cloths in your eyes, immediately wash them out with cool tap water.

  • Avoid applying Benzoyl Peroxide Cloths to raw or irritated skin, including sunburns or open wounds.

  • Several weeks may pass before you see improvement in your acne. Continue to use Benzoyl Peroxide Cloths for the full time recommended by your doctor. If your acne does not improve or if it gets worse, check with your doctor.

  • Talk with your doctor before you use any other medicines, special cleansers, aftershave, or cosmetics on your skin.

  • Benzoyl Peroxide Cloths may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Benzoyl Peroxide Cloths. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Benzoyl Peroxide Cloths may cause bleaching. Avoid contact with hair, fabrics, or carpeting.

  • Benzoyl Peroxide Cloths should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: It is not known if Benzoyl Peroxide Cloths can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Benzoyl Peroxide Cloths while you are pregnant. It is not known if Benzoyl Peroxide Cloths are found in breast milk. If you are or will be breast-feeding while you use Benzoyl Peroxide Cloths, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Benzoyl Peroxide Cloths:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dryness; feeling of warmth; irritation; itching; peeling; redness; stinging.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; dizziness; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive burning, itching, irritation, peeling, redness, or tenderness of your skin; extreme dryness; swelling.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Benzoyl Peroxide side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive scaling; flushing; redness; swelling.


Proper storage of Benzoyl Peroxide Cloths:

Store at room temperature, between 59 and 77 degrees F (15 and 25 degrees C) in a tightly closed container. Store away from fire, flame, heat, moisture, and light. Do not freeze. Keep Benzoyl Peroxide Cloths out of the reach of children and away from pets.


General information:


  • If you have any questions about Benzoyl Peroxide Cloths, please talk with your doctor, pharmacist, or other health care provider.

  • Benzoyl Peroxide Cloths are to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Benzoyl Peroxide Cloths. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Benzoyl Peroxide resources


  • Benzoyl Peroxide Side Effects (in more detail)
  • Benzoyl Peroxide Use in Pregnancy & Breastfeeding
  • Benzoyl Peroxide Drug Interactions
  • Benzoyl Peroxide Support Group
  • 15 Reviews for Benzoyl Peroxide - Add your own review/rating


Compare Benzoyl Peroxide with other medications


  • Acne
  • Perioral Dermatitis

Sunday, October 17, 2010

Azitromicina Winthrop




Azitromicina Winthrop may be available in the countries listed below.


Ingredient matches for Azitromicina Winthrop



Azithromycin

Azithromycin dihydrate (a derivative of Azithromycin) is reported as an ingredient of Azitromicina Winthrop in the following countries:


  • Spain

International Drug Name Search

Thursday, September 23, 2010

Diclofrot Gel




Diclofrot Gel may be available in the countries listed below.


Ingredient matches for Diclofrot Gel



Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Diclofrot Gel in the following countries:


  • Peru

International Drug Name Search

Thursday, September 16, 2010

Tiocolchicoside Pliva




Tiocolchicoside Pliva may be available in the countries listed below.


Ingredient matches for Tiocolchicoside Pliva



Thiocolchicoside

Thiocolchicoside is reported as an ingredient of Tiocolchicoside Pliva in the following countries:


  • Italy

International Drug Name Search

Wednesday, September 15, 2010

Prezista


Prezista is a brand name of darunavir, approved by the FDA in the following formulation(s):


PREZISTA (darunavir ethanolate - suspension; oral)



  • Manufacturer: TIBOTEC

    Approval date: December 16, 2011

    Strength(s): EQ 100MG BASE/ML [RLD]

PREZISTA (darunavir ethanolate - tablet; oral)



  • Manufacturer: TIBOTEC

    Approval date: February 25, 2008

    Strength(s): EQ 600MG BASE [RLD]


  • Manufacturer: TIBOTEC

    Approval date: October 21, 2008

    Strength(s): EQ 400MG BASE


  • Manufacturer: TIBOTEC

    Approval date: December 18, 2008

    Strength(s): EQ 150MG BASE, EQ 75MG BASE

Has a generic version of Prezista been approved?


No. There is currently no therapeutically equivalent version of Prezista available.


Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Prezista. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents


Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.




  • .alpha.-and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent 5,843,946
    Issued: December 1, 1998
    Inventor(s): Vazquez; Michael L. & Mueller; Richard A. & Talley; John J. & Getman; Daniel & DeCrescenzo; Gary A. & Freskos; John N.
    Assignee(s): G.D. Searle & Co.
    .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Patent expiration dates:

    • December 1, 2015
      ✓ 
      Patent use: TREATMENT OF HIV INFECTION IN ANTIRETROVIRAL TREATMENT-EXPERIENCED ADULT PATIENTS
      ✓ 
      Drug product


    • December 1, 2015
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN PEDIATRIC PATIENTS 6 YEARS OF AGE AND OLDER
      ✓ 
      Drug product


    • December 1, 2015
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN PEDIATRIC PATIENTS 3 YEARS OF AGE AND OLDER
      ✓ 
      Drug product


    • December 1, 2015
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN ADULT PATIENTS
      ✓ 
      Drug product


    • June 1, 2016
      ✓ 
      Pediatric exclusivity




  • Method for improving pharmacokinetics
    Patent 6,037,157
    Issued: March 14, 2000
    Inventor(s): Norbeck; Daniel W. & Kempf; Dale J. & Leonard; John M. & Bertz; Richard J.
    Assignee(s): Abbott Laboratories
    A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
    Patent expiration dates:

    • June 26, 2016
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN PEDIATRIC PATIENTS 3 YEARS OF AGE AND OLDER


    • June 26, 2016
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN PEDIATRIC PATIENTS 6 YEARS OF AGE AND OLDER


    • December 26, 2016
      ✓ 
      Pediatric exclusivity




  • .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent 6,248,775
    Issued: June 19, 2001
    Inventor(s): Vazquez; Michael L. & Mueller; Richard A. & Talley; John J. & Getman; Daniel P. & DeCrescenzo; Gary A. & Freskos; John N. & Bertenshaw; Deborah E. & Heintz; Robert M.
    Assignee(s): G. D. Searle & Co.
    .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Patent expiration dates:

    • August 13, 2014
      ✓ 
      Drug substance


    • February 13, 2015
      ✓ 
      Pediatric exclusivity




  • &agr;-and &bgr;-amino acid hydroxyethlamino sulfonamides useful as retroviral protease inhibitors
    Patent 6,335,460
    Issued: January 1, 2002
    Inventor(s): Michael L.; Vazquez & Richard A.; Mueller & John J.; Talley & Daniel; Getman & Gary A.; DeCrescenzo & John N.; Freskos
    Assignee(s): G.D. Searle & Co.
    &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Patent expiration dates:

    • August 25, 2012
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN PEDIATRIC PATIENTS 6 YEARS OF AGE AND OLDER
      ✓ 
      Drug substance
      ✓ 
      Drug product


    • August 25, 2012
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN ADULT PATIENTS
      ✓ 
      Drug substance
      ✓ 
      Drug product


    • August 25, 2012
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN PEDIATRIC PATIENTS 3 YEARS OF AGE AND OLDER
      ✓ 
      Drug substance
      ✓ 
      Drug product


    • August 25, 2012
      ✓ 
      Patent use: TREATMENT OF HIV INFECTION IN ANTIRETROVIRAL TREATMENT-EXPERIENCED ADULT PATIENTS
      ✓ 
      Drug substance
      ✓ 
      Drug product


    • February 25, 2013
      ✓ 
      Pediatric exclusivity




  • Method for improving pharmacokinetics
    Patent 6,703,403
    Issued: March 9, 2004
    Inventor(s): Daniel W.; Norbeck & Dale J.; Kempf & John M.; Leonard & Richard J.; Bertz
    Assignee(s): Abbott Laboratories
    A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
    Patent expiration dates:

    • June 26, 2016
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN PEDIATRIC PATIENTS 6 YEARS OF AGE AND OLDER


    • June 26, 2016
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN PEDIATRIC PATIENTS 3 YEARS OF AGE AND OLDER


    • December 26, 2016
      ✓ 
      Pediatric exclusivity




  • Fitness assay and associated methods
    Patent 7,470,506
    Issued: December 30, 2008
    Inventor(s): Erickson; John W. & Gulnik; Sergei V. & Mitsuya; Hiroaki & Ghosh; Arun K.
    Assignee(s): The United States of America as represented by the Department of Health and Human Services
    Board of Trustees of the University of Illinois
    The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy. The present invention also provides a compound of formula (I) or a pharmaceutically acceptable salt, a prodrug, a composition, or an ester thereof, wherein A is a group of formulas (A), (B), (C) or (D); R1, R2, R3, R5 or R6 is H, or an optionally substituted and/or heteroatom-bearing alkyl, alkenyl, alkynyl, or cyclic group; Y and/or Z are CH2, O, S, SO, SO2, amino, amides, carbamates, ureas, or thiocarbonyl derivatives thereof, optionally substituted with an alkyl, alkenyl, or alkynyl group; n is from 1 to 5; X is a bond, an optionally substituted methylene or ethylene, an amino, O or S; Q is C(O), C(S), or SO2; m is from 0 to 6; R4 is OH, ═O (keto), NH2, or alkylamino, including esters, amides, and salts thereof; and W is C(O), C(S), S(O), or SO2. Optionally, R5 and R6, together with the N—W bond of formula (I), comprises a macrocyclic ring.
    Patent expiration dates:

    • June 23, 2019
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN PEDIATRIC PATIENTS 6 YEARS OF AGE AND OLDER


    • June 23, 2019
      ✓ 
      Patent use: TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN ADULT PATIENTS, AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN PEDIATRIC PATIENTS 3 YEARS OF AGE AND OLDER


    • December 23, 2019
      ✓ 
      Pediatric exclusivity




  • Pseudopolymorphic forms of a HIV protease inhibitor
    Patent 7,700,645
    Issued: April 20, 2010
    Inventor(s): Vermeersch; Hans Wim Pieter & Thoné; Daniel Joseph Christiaan & Janssens; Luc Donné Marie-Louise
    Assignee(s): Tibotec Pharmaceuticals Ltd.
    New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate and processes for producing them are disclosed.
    Patent expiration dates:

    • December 26, 2026
      ✓ 
      Drug substance
      ✓ 
      Drug product


    • June 26, 2027
      ✓ 
      Pediatric exclusivity




  • α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent RE42889
    Issued: November 1, 2011
    Inventor(s): Vazquez; Michael L. & Mueller; Richard A. & Talley; John J. & Getman; Daniel P. & DeCrescenzo; Gary A. & Freskos; John N. & Heintz; Robert M. & Bertenshaw; Deborah E.
    Assignee(s): G.D. Searle LLC
    α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Patent expiration dates:

    • October 19, 2016
      ✓ 
      Drug product


    • April 19, 2017
      ✓ 
      Pediatric exclusivity



Related Exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

  • Exclusivity expiration dates:
    • June 23, 2011 - NEW CHEMICAL ENTITY

    • October 21, 2011 - EXPANSION OF INDICATION TO INCLUDE TREATMENT OF HIV IN TREATMENT NAIVE ADULTS

    • October 21, 2011 - TWO 400MG TABLETS ONCE DAILY, CO-ADMINISTERED WITH 100MG RITONAVIR

    • December 18, 2011 - NEW STRENGTH

    • December 18, 2011 - DOSING RECOMMENDATIONS FOR HIV INFECTED PEDIATRIC PATIENTS 6 TO LESS THAN 18 YEARS OF AGE

    • December 23, 2011 - PEDIATRIC EXCLUSIVITY

    • April 21, 2012 - PEDIATRIC EXCLUSIVITY

    • June 18, 2012 - PEDIATRIC EXCLUSIVITY

    • December 13, 2013 - 800/100 MG DARUNAVIR/RITONAVIR, ONCE DAILY, IN TREATMENT -EXPERIENCED HIV-1 INFECTED PATIENTS WITH NO DARUNIVIR RESISTANCE ASSOCIATED SUBSITUTIONS

    • June 13, 2014 - PEDIATRIC EXCLUSIVITY

    • December 16, 2014 - NEW PATIENT POPULATION

    • December 16, 2014 - NEW DOSAGE FORM

    • June 16, 2015 - PEDIATRIC EXCLUSIVITY

See also...

  • Prezista Consumer Information (Drugs.com)
  • Prezista Consumer Information (Wolters Kluwer)
  • Prezista Consumer Information (Cerner Multum)
  • Prezista Advanced Consumer Information (Micromedex)
  • Prezista AHFS DI Monographs (ASHP)
  • Darunavir Consumer Information (Wolters Kluwer)
  • Darunavir Consumer Information (Cerner Multum)
  • Darunavir Advanced Consumer Information (Micromedex)
  • Darunavir AHFS DI Monographs (ASHP)